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All patients on long-term therapy with this preparation should be questioned and examined periodicallyincluding the testing of knee and ankle reflexesto detect any evidence of muscular weaknessIf weakness occursdiscontinue the drug.

Antimalarial compounds should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

ChildrenThe safety and effectiveness of using this medication have not been established for children when used for the treatment of rheumatoid arthritis or systemic lupus erythematosusChildren are especially sensitive to the side effects of hydroxychloroquine.

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